Glucose, Energy and the Cerebellum
In the times directly before and during Emotional PMS symptoms, your cerebellum may be quickly burning through the body’s available supply of glucose.
When the cerebellum doesn’t get access to the glucose it needs, it can’t function properly. This triggers the body to crave quick, glucose spiking junk foods to remedy the problem. The dysfunctioning cerebellum causes all of the struggle associated with PMS like mood swings, melancholy, anxiety, sensitivity and stress.
It is also why many women aren’t just using junk food to comfort themselves, the ensuing sugar spike actually provides real relief from symptoms. Unfortunately, the relief is often only temporary. After the inevitable crash in sugar levels, symptoms return worse than before.
How To Keep The Cerebellum Energized and Functioning
Brain cells receive their energy from glucose and ketones in the blood. When blood sugar levels drop, the cerebellum can’t meet its higher energy needs before your period and can’t function properly, causing the emotional volatility of PMS.
Unfortunately, a high sugar diet isn’t the answer. As high levels of blood glucose are toxic, in response, the body releases insulin to drop them below baseline, creating another disruption of energy in the cerebellum.
The key to managing a stable, energized cerebellum is maintaining stable blood sugar levels, which gives the cerebellum a constant supply of energy.
Only a few lifestyle modifications have been shown to reliably decrease the severity of Emotional PMS symptoms. They all work through pathways that support a stable supply of blood sugar to the brain, with less severe highs and lows in blood sugar levels. They include:
- Regular aerobic exercise
- Regular High-Intensity Interval Training (HIIT)
- Diets with lower glycemic loads (less sugar and simple carbohydrates)
- Improved sleep hygiene (Regular, restful sleep for 8+ hours)
If you’re suffering from Emotional PMS, these are key lifestyle foundations to consider improving. However, for many, these changes only offer mild relief. And even women with picturesque healthy lifestyles of perfect diet, perfect exercise and great sleep routines still suffer from Emotional PMS every month.
We’ll explain the science of why, and the solution, but first allow us to introduce ourselves.
Our names are Kathy and Alan Cash, we run a family-owned biotech company called Terra Biological.
Hi, Nice to Meet You
We live in San Diego, have three grown daughters and a dog named Charlie.
When one of our daughters was in college, about once a month, we’d receive a series of calls from her. We could hear her distraught, sad, angry and suffering, asking us for help, but no words or anything we did would make her feel better.
The worst feeling as a parent is hearing your child in pain and not being able to help them. It would rip us up inside, and then one month would pass and it would happen all over again. It took us a long time to realize her suffering might be related to Emotional PMS, and even then, we didn’t know if there was anything that could help her.
Our company sells one product, a nutritional supplement with a compound Alan patented called thermally stabilized oxaloacetate (OAA). Mainly, we sell it to doctors who give it to patients for conditions related to chronic fatigue, blood sugar or aging.
One day, we got a phone call from one of our customers, Dr. Ghen. He told us that a few months ago, he gave OAA to one of his patients, an E.R. nurse who needed more energy in the days after a night shift.
The patient also needed help with Emotional PMS symptoms which significantly hindered her performance in high pressure situations. Since she had already tried hormonal birth control in the past, and the severe side effects weren’t worth the mild relief, Dr. Ghen told her she may be out of options.
At a checkup several months later, the patient told Dr. Ghen that her Emotional PMS symptoms had practically disappeared since taking OAA daily, and it had completely changed her career and home life.
Since oxaloacetate is just an over-the-counter supplement, Dr. Ghen started recommending it to any patient reporting Emotional PMS symptoms. He kept having the same great results.
When we heard this, Alan began to look into the science. Spending all day reading about Emotional PMS, it occurred to him that it may have something to do with our daughters’ sporadic suffering. We shipped her a bottle of OAA without much hope, but figured it couldn’t hurt.
Lo and behold, our daughter started calling us more regularly, but only to share a funny story or a grade she received. We waited a month and the anxious, distressed series of calls asking for help never came. She decided to keep taking OAA, as it kept her mind sharper in long classes, and the calls never came back.
There’s more to the story, but first, here’s a look into the science of why OAA is so helpful in relieving Emotional PMS symptoms.
The Science of Oxaloacetate, The Cerebellum and PMS
Cellular Energy Production
Every cell of your body contains certain energy metabolites. One of them, oxaloacetate, is a critical compound for mitochondria, the power plants of the cell responsible for more than 90% of the energy you need to live, think, breathe and move.
The liver plays a key role in gluconeogenesis, a vital process that provides the right amount of glucose to the brain. Oxaloacetate is required for gluconeogenesis to work. In fact, oxaloacetate is so crucial to the body’s functioning, babies born with low or no oxaloacetate suffer from impaired brain development or die as children.
Oxaloacetate is found in trace amounts in many common foods, and normally the body can find enough to survive without any problems. But during PMS, the cerebellum requires much larger amounts of sugar, and without enough oxaloacetate, the liver can’t keep up with the larger demand.
GABA, a neurotransmitter in the brain responsible for relieving anxiety and elevating mood, is always in a balancing act with glutamine, a neurotransmitter that, when in excess, causes toxic over-excitement of brain cells. Scientists have found that women with severe PMS symptoms experience far less activation of the GABA system in the days before their period.
As well, scientific studies have shown that when more oxaloacetate is available to neurons, the brain is better able to bring itself into balance, lowering levels of glutamate when there is too much and raising levels of GABA when there isn’t enough.
Finally, Scientific Proof – The Clinical Trials
The science made perfect sense, and the results from Dr. Ghen’s patients and other doctors kept trickling in. Our daughter was still feeling great all month long.
We knew this deserved further investigation. So we enlisted the help of more scientists and conducted two separate clinical trials. It took more than two years to organize and run both trials, compile the evidence and have the results evaluated by the FDA. But finally, in April of 2018, it was done.
Published in April of 2018, a double-blind, placebo-controlled trial registered with the National Institutes of Health found 100 mg of oxaloacetate, taken daily, highly effective in reducing PMS-related anxiety, gloomy mood, perceived stress (the unhealthy form of stress) and irritation.
Of more than 60 women in the trial suffering from Emotional PMS, on average, experienced
- Improvement in anxiety by 51%
- Improvement in melancholy mood by 54%
- Improvement in perceived stress by 36%
- Improvement in irritability by 18%
In fact, oxaloacetate was shown to be more effective in relieving symptoms of emotional PMS than any other over-the-counter solution ever tested in a clinical trial. You can read more about the clinical trial details at the National Institues of Health site here: https://clinicaltrials.gov/ct2/show/NCT03509714
These results are on par with, or better than, the results from trials for antidepressants and hormonal birth control prescribed for Emotional PMS. Moreso, these prescription medications generally require three months or more to take effect. Our clinical trials of oxaloacetate only lasted one month, beginning directly after each participant’s menstrual cycle.
“I am just beyond words…I have taken supplements that worked but NOTHING has worked this well. These eliminated my mood swings…Simply put, I feel like a demon has taken over my body…I have found my solution and I am beyond happy. It is like a 1000 pound weight taken off my shoulders. THANK YOU THANK YOU THANK YOU!!! And I know it is the supplements because this will be the 3rd month…that is NOT a coincidence.”
“I started noticing a significant difference in my PMS symptoms right around the 40-year mark. My PMS symptoms were becoming so extreme that they were derailing my life and starting to have an extremely negative impact on my relationships with family and friends. I did some internet research and stumbled on a clinical trial for severe PMS symptoms. The difference in my life after starting to take Jubilance is significant. I feel normal again. I no longer dread that time of the month—no more crippling frustration, irrational irritability and exhaustion with life in general. I don’t know how it works, I just know it does. I intend to continue taking Jubilance for the sake of every person who experiences a better me for having found it.”
My PMS symptoms had become so severe that it was affecting not only my everyday life but taking a major toll on my marriage as well. My husband actually found the PMS clinical trial for me, because we were desperately grasping at straws to improve my moods and general disposition. I noticed an immediate change as soon as I started taking it and could easily tell the difference between the product and the placebo. It improved my moods greatly, and honestly was a wonder supplement. I wish I had heard about Jubilance before, as there were many very trying days. I’m forever grateful to my husband for finding the trial, and to the researchers for making this product accessible.
– Elizabeth (clinical trial participant)
“I just saw a patient today, an ICU nurse who is 28 and very put together—except for one day a month, right before her period, where she sinks into a state of gloom and irritability. She told me she took oxaloacetate last month…her words were “it was like magic.” She said it didn’t take all the mild sadness/symptoms away, but she was so grateful that it brought down the whole situation into the manageable stage, where she could control it with her mind. This is a typical story, that oxaloacetate really relieves PMS problems reliably and promptly. The only thing somewhat different about this patient is that the degree of emotion is greater than usual—but not too unusual. You really have the answer to emotional PMS!
– Dr. John Humiston
These are just from our first wave of customers who heard about Jubilance from friends, family or were recommended by doctors.
To help get the word out faster, we made this page to make a special offer just for the first bottle purchased.
A 30-day supply bottle of Jubilance costs $49 or $42 with a monthly subscription.
Through this page only, you can receive a 30-day supply bottle for $9.95 to give Jubilance a try. It’s the best way we can think of helping more women see if Jubilance will work for them.
You have probably tried other supplements for PMS before. There is no shortage of companies that will sell you any type of herbs or berries they can fit in a pill. We have even seen bee pollen for sale for PMS. However, what is lacking from many of these other “remedies” is any type of clinical trial to measure if they truly work. Jubilance is backed by science, with verified results.
We would also like to provide you with a means to test Jubilance with more specificity to measure exactly how well Jubilance improves which of your symptoms. So along with the $9.95 bottle, we will send you a link to a free Emotional PMS questionnaire toolkit to track the effects of Jubilance.
It is designed specifically for PMS, but can track more than just the impact of oxaloacetate. The quiz can help you identify how you feel, and how the things you eat, the supplements that you take, the exercise you participate in and the people around you all help or hinder Emotional PMS.
Also, we will send every $9.95 initial purchase a free copy of our ebook “Fighting Emotional PMS and Winning with Jubilance,” which sells on Amazon for $16.95. The book is just 57 pages and can be read in a single sitting. But it is packed with information. It includes,
- Which Emotional PMS symptoms are the most common (even though nobody discusses them publicly)
- The biological processes that can affect Emotional PMS
- Certain foods that greatly increase Emotional PMS, such as those high in glutamate.
- More information on the clinical study of oxaloacetate’s effectiveness in improving Emotional PMS symptoms
- Real-life experiences of women who have overcome Emotional PMS
BUTTON: I would like to try Jubilance for just $9.95
80 percent of women experience Emotional PMS at some point in their lives.
And for centuries, too many have been told to just “deal with it” or worse, because of the belief that suffering through uncontrollable emotion each month is just an unfortunate reality of being born female.
We are sick of it.
We really want to get the word out fast, far and wide. We know the best way to do that is by getting it into the hands of real people, letting them experience the benefits and having them tell thier friends and family.
So we want to make our initial offer irresistible. Here’s our best shot:
For $9.95 you receive,
- 30-day supply of Jubilance (1 bottle) for $9.95 (a $49.00 value on Amazon)
- Lifetime access to the Emotional PMS toolkit
- A free copy of our book “Fighting Emotional PMS” (a $16.95 value on Amazon)
- FREE shipping for anyone in the USA
- 50% off coupon for your next bottle of Jubilance (one time only)
- 100% money back guarantee. If you don’t like it, just shoot us an email and we’ll issue a full refund.
Are you ready to improve your Emotional PMS?
BUTTON: Try Jubilance one time for $9.95, free shipping
Got any questions? We’d love to help. Email us at [email protected] and [email protected]