If you’ve been told your hormones are the cause of your PMS mood swings, you’re not getting the full story.
Doctors have said for years that the emotional symptoms of PMS, like Anxiety, Gloomy Mood, Stress, Mood Swings, Anger and Irritability, are due to shifting hormone levels before a period.
But a body of new scientific research indicates that while hormones play a role in the timing of Emotional PMS, they are not the only underlying cause of these symptoms.
In fact, recent studies show that women who experience severe PMS symptoms and those who experience no symptoms at all have no difference in hormone levels throughout the menstrual cycle. (Biggs, 2011).
Instead, research is showing that the Emotional PMS rollercoaster is caused by changes in how glucose (sugar) is metabolized in the brain and triglycerides (fat) are processed in the liver.
This means that there may be another approach to treating Emotional PMS.
The standard treatment for PMS, hormonal birth control, suppresses the body’s routine hormonal cycling and may not address the true cause of the problem.
Do you experience sugar cravings before your period?
Many women do, especially if the sugar is combined with a bit of fat, such as in chocolate bars and ice cream. The body is often more intelligent than we give it credit for, and it craves what it needs.
Before your period that need is sugar, which it needs specifically in the cerebellum, a part of the brain in charge of “primitive” emotions.
When dysfunctioning from lack of glucose, the cerebellum has been shown to cause Irritability, Anger, Low Mood and Mood Swings. (Schmahmann, 2019).
Glucose, Energy and the Cerebellum
In the times directly before and during Emotional PMS symptoms, your cerebellum may be quickly burning through the body’s available supply of glucose. (Trout, 2008).
When the cerebellum doesn’t get access to the glucose it needs, it can’t function properly. This triggers the body to crave quick, glucose spiking junk foods to remedy the problem.
The dysfunctioning cerebellum causes all of the struggle associated with PMS like mood swings, gloominess, anxiety, sensitivity, and stress.
It is also why many women aren’t just using junk food to comfort themselves, as the sugar spike provides real relief from mood symptoms. Unfortunately, relief is often only temporary. (Michener, 1999).
Unfortunately, due to the way our bodies process sugar, high initial blood sugar levels cause a release in insulin, and then sugar levels crash.
After the inevitable crash in sugar levels, symptoms return even worse than before.
How To Keep Your Cerebellum Energized and Functioning
Brain cells receive their energy from glucose and ketones in the blood.
When blood sugar levels drop, the cerebellum can’t meet its higher energy needs before your period.
Lack of energy causes dysfunction, felt as the emotional volatility of PMS. You may have felt this at other times when you are hungry.
Unfortunately, a high sugar diet isn’t the answer.
As high levels of blood glucose are toxic, in response, the body releases insulin to drop them below baseline, creating a more severe disruption of glucose in the cerebellum than before.
In addition, diets high in simple sugars have been shown to increase incidence of depression over the long term. (Gangwisch, 2015).
The key to maintaining a healthy, energized cerebellum is maintaining stable blood sugar levels, which gives the cerebellum a constant supply of energy, and maintaining healthy cellular metabolism, so brain cells can use that supply of energy quickly and efficiently.
Only a few lifestyle modifications have been shown to reliably decrease the severity of Emotional PMS symptoms.
They all work through pathways that support a stable supply of blood sugar to the brain, with less severe highs and lows in blood sugar levels. (Tsai, 2016).
- Regular practice of yoga
- Regular aerobic exercise
- Regular High-Intensity Interval Training (HIIT)
- Diets with lower glycemic loads (less sugar and simple carbohydrates)
- Improved sleep hygiene (Regular, restful sleep for 8+ hours)
However, for many women, these changes only offer mild relief.
And even women with picturesque healthy lifestyles still suffer from Emotional PMS every month.
We’ll explain the science of why this happens, and a potential solution identified in the research, but first allow us to introduce ourselves.
Hi, Nice to Meet You
I’m Kathy Cash. My husband Alan Cash and I run a small, family-owned biotech company called Terra Biological.
We live in San Diego, have three grown daughters and a dog named Charlie.
When one of our daughters went off to college, we used to receive a series of phone calls from her at the same time each month. We could hear her distraught, sad, angry and suffering, asking us for help, but no words or anything we did would make her feel better.
The worst feeling as a parent is hearing your child in pain and not being able to help them. It would rip us up inside, and then a month would pass and it would happen all over again.
It took us a long time to realize her suffering might be related to Emotional PMS, and even then, we didn’t know if there was anything that could help her.
Our company sells just one product, a nutritional supplement with a compound Alan (a physicist) and his team of researchers created called thermally stabilized oxaloacetate (OAA).
Mostly, we sell it to doctors who give it to patients for conditions related to fatigue, blood sugar and anti-aging.
Since Alan created it 12 years ago, more than 5 million doses have been sold worldwide.
The Phone Call That Changed Everything
One day, we got a phone call from one of our customers, Dr. Humiston. He told us that a few months ago, he gave OAA to one of his patients, an E.R. nurse who needed more energy after a night shift.
The patient also needed help with Emotional PMS symptoms which hindered her focus in high-pressure situations. Since she had already tried hormonal birth control in the past, and her lifestyle was already fairly healthy, Dr. Humiston didn’t have much to offer her.
At a checkup several months later, the patient told Dr. Humiston that her emotional PMS symptoms had practically disappeared since taking OAA daily, and it had completely changed her career and home life.
Since oxaloacetate is just an over-the-counter supplement, Dr. Humiston started recommending it to any patient reporting PMS symptoms.
He kept hearing similar positive results. A couple months later, we received another email,
“Alan… I am up to almost 30 women treated for moody PMS….I have only had one failure for moody PMS. Every other woman who has given me feedback (the majority of the 28-30 patients) has said that it substantially …resolves the mild PMS symptoms, in a short time from taking the supplement…..”
When we heard this, Alan and his research team began to look into the science.
After researching Emotional Premenstrual Syndrome, it occurred to him that it may have something to do with our daughter’s sporadic suffering.
So we crossed our fingers and shipped her a bottle of OAA.
Lo and behold, the next time our daughter called, she had stories to share, grades to brag about and sounded like herself again.
We waited a month but the anxious, desperate voice never came back.
Here’s what scientists know about OAA and why it’s so effective in relieving Emotional PMS symptoms.
The Science of Oxaloacetate, the Cerebellum and PMS
OAA’s role in the cell
Oxaloacetate is an energy metabolite compound used in the Kreb’s cycle, the system that mitochondria use to produce energy from glucose.
The Kreb’s cycle, and the oxaloacetate needed to keep it functioning, is crucial to the body’s functioning. In fact, babies born with low or no oxaloacetate suffer from impaired brain development or die as children.
Increased Liver Function
The liver plays a key role in gluconeogenesis, a vital process that provides the right amount of glucose to the brain. Oxaloacetate is required for gluconeogenesis to work.
Normally, the body can produce enough OAA to survive without any problems, and it is found in trace amounts in many common foods. Any food with a high density of mitochondria (peas and pigeon breast have some of the highest amounts) will contain a small but measurable amount of OAA.
But during PMS, the cerebellum requires much larger amounts of sugar, and without enough oxaloacetate, the liver can’t keep up with the larger demand.
Supplementing with oxaloacetate allows fatty acids to be converted into glucose, stabilizing glucose need with demand.
Healthy Brain Function
GABA, a neurotransmitter in the brain responsible for relieving anxiety and elevating mood, is always in a balancing act with glutamine, a neurotransmitter that, when in excess, causes toxic over-excitement of brain cells.
Scientists have found that women with severe PMS symptoms experience far less activation of the GABA system in the days before their period. (Lui, 2015).
As well, scientific studies have shown that when oxaloacetate is supplemented, the brain is better able to bring itself into balance, lowering levels of glutamate when there is too much and raising levels of GABA when there isn’t enough. (Wilkins, 2014).
Real Women, Real Results – The Clinical Trials
The science made sense, and the results from Dr. Humiston’s patients and other doctors kept trickling in. Our daughter was still feeling great.
We knew this deserved further investigation. So we enlisted the help of more scientists and conducted two separate clinical trials.
Two years later we had completed two clinical trials, compiled the evidence and the study was posted by the National Institutes of Health.
Two double-blind, placebo-controlled trials found that oxaloacetate, taken daily, relieves PMS-related Anxiety, Gloomy Mood, Perceived Stress (the unhealthy form of stress) and Irritation.
Women suffering from Emotional PMS experienced:
- Improvement in PMS-related Anxiety by 51%
- Improvement in PMS-related Gloominess by 54%
- Improvement in PMS-related Stress by 36%
- Improvement in PMS-related Irritability by 18%
The data support a “function/structure” claim:
“Oxaloacetate may help alleviate the mild to moderate psychological and/or behavioral symptoms associated with Premenstrual Syndrome (PMS).”
Last year, we launched Jubilance, an oxaloacetate supplement specifically for Emotional PMS relief.
Our First Reviews Are Exciting!
Here’s a conversation posted on March 22, 2019, from our private Facebook group for Jubilance customers (we hid names and faces, but if you would like to ask these women about their experience, you can request to join the Facebook Group here: facebook.com/groups/byePMS/
Since launching last year, Jubilance has already earned a 4.8 out of 5 star customer rating on Amazon. Here are some of our favorite reviews:
These comments on our Facebook ads had us beaming 🙂
Of the more than 2,000 women who have tried Jubilance so far (as of August 2019), 76% join our monthly subscription program to get Jubilance every single month.
Of the many things we must overcome in life as women, one that’s never talked about seriously is the lifetime toll of emotional PMS symptoms.
No matter how resilient your character, you can’t “tough out” symptoms that take away your ability to control your own thoughts, emotions and mindset. Finally, there is a solution that can help us live without that extra burden.
I think that’s a big deal. So rather than a big “macho” ad campaign, we want to use the power of women supporting women to spread the word and get Jubilance to as many women in need as possible.
That’s why we made this page with a special offer just for the first bottle purchased.
A 30-day supply bottle of Jubilance costs $49 plus shipping.
With a monthly subscription, renewing every four weeks, Jubilance only costs $42 with free shipping.
But right now, through this page only, you can receive the first bottle in a monthly subscription, a 30-day supply bottle, for only $19.95 with free shipping.
It’s the best way we can think of helping more women see if Jubilance will work for them.
First-Time Trial Subscription
- Free Shipping
- Cancel-Anytime Monthly Subscription
- 100% Money Back Guarantee
- Free eBook “Fighting Emotional PMS and Winning” ($16 value)
- Free Mood Relief Quiz to Track Symptom Improvement
- Invitation to Private Facebook Community “Bye PMS”
- Free Shipping
- Cancel-Anytime Monthly Subscription
- 100% Money Back Guarantee
- Shipping ($8.50) Not Included
- 100% Money Back Guarantee
You have probably tried other PMS supplements before.
There is no shortage of companies that will sell you any type of herbs or berries they can fit in a pill. We have even seen bee pollen for sale for PMS.
However, what is lacking from many of these other “remedies” is any type of clinical trial to measure if they truly work. Jubilance is backed by science, with verified results.
Every capsule of Jubilance contains the same formula shown to relieve emotional PMS symptoms in clinical research.
This trial offer comes with our No-Questions-Asked 100% Money-Back Guarantee.
If Jubilance isn’t for you, shoot us an email and we’ll issue a full refund. No hoops to jump through. No time limits.
We would also like to provide you with a means to test Jubilance with more specificity to measure exactly how well Jubilance improves which of your symptoms.
So along with your $19.95 trial bottle, we will send you a link to a free Mood Relief Quiz to track the effects of Jubilance.
It is designed specifically for PMS, but can track more than just the impact of oxaloacetate.
The quiz can help you identify how you feel, and how the things you eat, the supplements that you take, the exercise you participate in and the people around you all help or hinder Emotional PMS.
Also, we will send every $19.95 initial purchase a free copy of our ebook “Fighting Emotional PMS and Winning with Jubilance,” which sells on Amazon for $16.95.
The book is just 57 pages and can be read in a single sitting. But it is packed with information. It includes,
- Which Emotional PMS symptoms are the most common (even though nobody discusses them publicly)
- The biological processes that can affect Emotional PMS
- Certain foods that greatly increase Emotional PMS, such as those high in glutamate.
- More information on the clinical study of oxaloacetate’s effectiveness in improving Emotional PMS symptoms
- Real-life experiences of women who have overcome Emotional PMS
- Small diet and exercise techniques that increase the effectiveness of oxaloacetate and further improve Emotional PMS.
You are not alone. 80 percent of women experience Emotional PMS at some point in their lives.
And for centuries, too many have been told to just “deal with it” or worse, because of the belief that suffering through uncontrollable emotion each month is just an unfortunate reality of being born female.
We are sick of it.
We really want to get the word out fast, far and wide. We know the best way to do that is by getting it into the hands of real people, letting them experience the benefits and having them tell their friends and family.
So we want to make our initial offer irresistible. Here’s our best shot:
For $19.95 you will receive,
- 30-day supply of Jubilance (1 bottle) for $19.95 (a $49.00 value on Amazon)
- Free Lifetime access to the Mood Relief Quiz to track your symptoms
- A free copy of our book “Fighting Emotional PMS” (a $16.95 value on Amazon)
- FREE shipping for anyone in the USA
- 100% money back guarantee. If you don’t like it, just shoot us an email and we’ll send a full refund.
Questions? We’d love to help.
Ask us anything at 858-947-5722 or firstname.lastname@example.org.
Kathy and Alan Cash
Terra Biological, creators of Jubilance
3830 Valley Centre Drive
#705 PMB 561
San Diego, CA 92130
(1, 2) (3, 4) (5-7)
- Biggs WS, Demuth RH. Premenstrual syndrome and premenstrual dysphoric disorder. Am Fam Physician. 2011;84(8):918-24.
- Schmahmann JD. The cerebellum and cognition. Neurosci Lett. 2019;688:62-75.
- Gangwisch JE, Hale L, Garcia L, Malaspina D, Opler MG, Payne ME, et al. High glycemic index diet as a risk factor for depression: analyses from the Women’s Health Initiative. Am J Clin Nutr. 2015;102(2):454-63.
- Tsai SY. Effect of Yoga Exercise on Premenstrual Symptoms among Female Employees in Taiwan. Int J Environ Res Public Health. 2016;13(7).
- Liu B, Wang G, Gao D, Gao F, Zhao B, Qiao M, et al. Alterations of GABA and glutamate-glutamine levels in premenstrual dysphoric disorder: a 3T proton magnetic resonance spectroscopy study. Psychiatry Res. 2015;231(1):64-70.
- Wilkins HM, Harris JL, Carl SM, E L, Lu J, Eva Selfridge J, et al. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Hum Mol Genet. 2014;23(24):6528-41.
- Zlotnik A, Gruenbaum SE, Artru AA, Rozet I, Dubilet M, Tkachov S, et al. The neuroprotective effects of oxaloacetate in closed head injury in rats is mediated by its blood glutamate scavenging activity: evidence from the use of maleate. J Neurosurg Anesthesiol. 2009;21(3):235-41.
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