Premium, Patented and Proven: The Powerful Science of Thermally Stabilized Oxaloacetate
The PMS relief supplement Jubilance contains a single active ingredient, thermally stabilized oxaloacetate (also known as “OAA”) and is paired with Vitamin C to ensure maximum bioavailability. OAA is a key metabolite found in every cell of your body that is vital to energy production, glucose system support and overall proper cellular functioning.
The patented active ingredient OAA in Jubilance is manufactured in gold standard cGMP facilities.
Emotional symptoms in PMS have been significantly tied to increased glucose need in the cerebellum of the brain. In clinical trials, Oxaloacetate supplementation has increased cellular uptake of glucose, including direct increase of brain glucose uptake. 6 7
Proven Clinical Trial Results
Peer-reviewed clinical trials by the Journal of Obstetrics and Gynecology and archived by the National Institutes of Health show that Jubilance’s patented OAA and Vitamin C formula showed significant results in relieving PMS mood swings. 5
After reviewing the clinical trial results and testimonials from patients and doctors, the Food and Drug Administration (FDA) has allowed Jubilance’s “Structure/Function” claim, one of the first in history for an over-the-counter PMS mood solution.
“Oxaloacetate may help alleviate the mild to moderate psychological and/or behavioral symptoms associated with Premenstrual Syndrome (PMS).”
Full Clinical Trial ResultsProven Clinical Trial Results
Oxaloacetate Can Improve Your PMS Mood Symptoms
How Blood Sugar Levels Play a Role
There is a good reason why you get sugar and fat cravings before your period.
Scientific studies show that, during PMS, women with severe PMS mood symptoms send much larger amounts of glucose to a specific area of the brain, the cerebellum. 1
If there is not enough glucose (energy), the cerebellum can’t properly perform important functions like:
- Mood regulation
- Managing fear responses
- Managing pleasure responses
- Motor control
This dysfunction in the cerebellum causes all the horrid PMS mood symptoms with which many of us are all too familiar:
- Anxiety
- Gloominess
- Stress
- Irritability
You may have experienced these same mood alterations to a lesser degree outside of PMS when you are hungry and low on blood sugar.
Fuel Your Brain With On-Demand Energy
Your body is smart. Ravenous carb and fat cravings are the cerebellum yelling, “Give me more energy NOW!” This is why chocolate, chips and ice cream provide real short-term relief from PMS mood symptoms—and why adjusting hormones did not remove these cravings. 2
But because of the way we metabolically process sugar in these high carb foods, the short-term improvements are quickly lost as we sugar crash leaving the cerebellum with less energy (and more anxiety, gloominess, stress, and irritation) and making us feel worse than before. 3
Oxaloacetate (Jubilance’s active ingredient) works in the liver to support the process of turning fatty acids into glucose 4 so the sugar energy is readily available for the cerebellum when it needs it most. A well-fed cerebellum overcomes the problem of a hungry brain.
In clinical trials, this translated to less mood swings, with 80% of the women receiving the benefits of reduced anxiety and perceived stress, a happier mood and less irritation. 5
In just one month
54%
Gloominess
51%
Anxiety
35%
Stress
18%
Irritability
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One Capsule A Day Keeps The Mood Swings Away
Jubilance is the most advanced scientific solution to PMS mood symptom relief! Women who took Jubilance daily for just one month experienced an improvement in PMS-related gloominess, anxiety, stress and irritability.
Ready to try Jubilance for your PMS mood symptoms? Subscribe and save or order your Starter Bottle today!
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Dig into the full clinical trial results
Discuss the references below with your doctor
Scientific References
- Liu B, Wang G, Gao D, Gao F, Zhao B, Qiao M, et al. Alterations of GABA and glutamate-glutamine levels in premenstrual dysphoric disorder: a 3T proton magnetic resonance spectroscopy study. Psychiatry Res. 2015;231(1):64-70.
- Michener W, Rozin P, Freeman E, Gale L. The role of low progesterone and tension as triggers of perimenstrual chocolate and sweets craving: some negative experimental evidence. Physiol Behav. 1999;67(3):417-20.
- Mantantzis K, Schlaghecken F, Sunram-Lea SI, Maylor EA. Sugar rush or sugar crash? A meta-analysis of carbohydrate effects on mood. Neurosci Biobehav Rev. 2019;101:45-67.
- Marco R, Pestana A, Sebastian J, Sols A. Oxaloacetate metabolic crossroads in liver. Enzyme compartmentation and regulation of gluconeogenesis. Mol Cell Biochem. 1974;3(1):53-70.
- Tully L, Humiston J, Cash A. Oxaloacetate reduces emotional symptoms in premenstrual syndrome (PMS): results of a placebo-controlled, cross-over clinical trial. Obstet Gynecol Sci. 2020;63(2):195-204.
- Yoshikawa K. Studies on the anti-diabetic effect of sodium oxaloacetate. Tohoku J Exp Med. 1968;96(2):127-41.
- Vidoni ED, Choi IY, Lee P, Reed G, Zhang N, Pleen J, et al. Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients. Alzheimers Dement. 2020.
