How Women Across the U.S. Are Using Science To Stop PMS Mood Swings For Good

(without altering their female hormones)

A 12 minute read describing…

  • The simple, science-based method to end the constant struggle with PMS 
  • Why carb and fat cravings point to the root cause of emotional PMS symptoms 
  • Why the age-old paradigm of “PMS is just your hormones,” is missing a major piece of the story 
  • The double-blind, placebo-controlled clinical trials that significantly lowered PMS symptoms in 83% of participants

When it’s bad, PMS is not just a headache.

It can flip a switch that turns life from good to miserable.

  • The crippling anxiety about things that normally roll off your back…
  • The flood of emotions that overwhelm you out of nowhere…
  • The hair-trigger anger that puts words in your mouth you’d never otherwise say…
  • The junk food cravings that derail all the healthy habits you work so hard to build…
PMS sucks


Finally, we can put this outdated belief behind us.

Today, scientific studies have given us a strong picture of the biological mechanisms behind PMS and how to address it at its root cause.

Since June 2017, a new non-hormonal, non-pharmaceutical method for treating the emotional symptoms of PMS has been spreading to doctors offices and thousands of women.

It is based on a new placebo-controlled clinical trial that lowered a spectrum of emotional PMS symptoms more significantly than anything tested in the past.

If you’re ready to…

  • Free up all the energy you spend dealing with PMS each month…
  • Seize the potential that has been trapped under your monthly PMS symptoms…
  • Bring your true, authentic self to your relationships all month long…
  • Enjoy all the best moments of life without worrying about looming PMS…

But before you do…

Please know, all bodies are different, and the method described here does not work for every woman.

It also may not resolve all of your PMS symptoms completely.

However, in placebo-controlled clinical trials, 83% of women following the science-based method outlined here experienced significant, life-changing PMS relief.

If you’re willing to try something new, this article might hold the scientific data you need to finally get the PMS relief, and the life, you deserve.


My name is Kathy Cash. Two years ago, my daughter and I embarked on a mission we never expected: to empower 100,000 women to live life without PMS by 2022.

Everything in our culture, including far too many doctors, tells us that PMS is just an unfortunate, unchangeable part of life as a woman.

And yet, in the last year we’ve already heard from thousands of women who have used new scientific advances to live a life free from the constant burden of PMS.

Here are some of our favorites:

Emma Burley Jubilance Review

“Normally, my mood swings kick in on the 20th of every month, and begins 10-12 days of extremely emotional PMS before flow comes to town.

I get dizzy, extremely moody, teary, and overall just feel helpless.

I started about three weeks before my mood swings usually start.

Let me tell you, the 20th rolled around, and I felt fine, then the 21st, then the 22nd, then the 23rd… and no negative emotions, no dark thoughts, no crying…. now, get this.

I DID NOT GET PMS! I swear to the effin ladygods, I was completely fine. I did not cry, I did not lash out, I did not say that I was going to give up…. I literally felt fine.

I cannot believe it. I have not been PMS free in years.”

– Emma Burley, makeup artist

Susan Patterson reviews Jubilance pms anxiety


“As I’ve gotten older, I’m 39 now, PMS gradually morphed into a mental issue where the moodiness turned into massive amounts of anxiety.

It was a Jekyll and Hyde thing that I couldn’t figure out.

It would increasingly get worse [after ovulation], and there were times that PMS lasted as long as two weeks. And so, it turned into this joke that I have one good week out of the month.

I tried everything…

I’ve tried lowering my stress level or my schedule, I’ve tried the antidepressants, I’ve tried massive diet changes, birth control options and nothing worked at all.

And so, I came across this and I thought, “I have nothing to lose! So, let’s give it a go!”

After starting I noticed an immediate difference.

It was pretty instantaneous. I was a good five days out before my period would start. And I was like, “I’m still human, check me out, I’m human! This is amazing!”

I still had some symptoms, but they were so decreased, they were so much less.

And it came with a really insane clarity for me this last month of like, “Okay, I’m not totally crazy here, there’s something to it, I don’t just one week love all these things in life and then the next week hate everything.”

– Susan Patterson, Airline Pilot

Kolette Sisk Reviews Jubilance PMS anxiety

“After I had my daughter, my PMS symptoms became unmanageable.

I would have two good weeks and then two terrible, long, miserable weeks.

I would get very angry, moody, mean, anxious, sad, and irrational.

I would convince myself that I was a terrible mother. It was rough, but once my period would start I would be happy, calm, and my normal self.

I went to my doctor and was given continuous birth control. The idea being, that if I would skip my periods, I would skip the hormonal shifts. Sounds good in theory but this did not happen at all. I was even worse!

I started doing my own research and stumbled upon OAA and that has been life changing!!!

I’ve only been taking it for two months but my life is 100% better!

I’ve had two straight months of no PMS at all! 60 days of being level headed, happy and calm.

No more calling out sick from work. No more cursing my husband out over silly, trivial things. No more feeling like the worst, most incompetent mother on the planet. No more convincing myself of totally irrational things!”

– Kolette Sisk, Rural Mail Carrier



If you talk to doctors not well-versed in the latest science of women’s health (as many unfortunately are), they will tell you this is simply impossible.

And yet, more women break free from PMS every month, without altering their natural hormone cycling.

For decades, the dominant medical paradigm has been that PMS is caused solely by hormone shifts before menstruation.

But this pseudo-scientific conclusion misses something key…

hormones dont tell the whole story pms

A body of new scientific research indicates that while hormones determine the timing of PMS, they are not the underlying cause of these symptoms.

In fact, recent studies show that women who experience severe PMS symptoms, and those who experience no symptoms at all, have no difference in hormone levels throughout the menstrual cycle. (Biggs, 2011).

How Glucose is Metabolized in the Brain


Most women do, and for good reason. The body is often more intelligent than we give it credit for, and it craves what it needs.

Studies show that eating a single chocolate bar (a food with both quick-digesting sugars and fats) doesn’t just provide a distraction from the struggle of PMS, it actually lowers the severity of emotional symptoms. (Michener, 1999).

Recent brain scan studies give a major clue for the reason why junk foods can relieve PMS symptoms, at least temporarily.

When scientists scanned the brains of women experiencing PMS, they saw an abnormally large spike in glucose (sugar) uptake in a specific region of the brain called the cerebellum. (Liu, 2015).

When scientists scanned the brains of women that don't experience PMS, no such glucode spike occured. - ( Liu, 2015 )

This spike in glucose uptake is a sign that the cerebellum is in need of more energy than normal.

When the cerebellum is damaged, or unable to obtain enough glucose, studies show that patients (both men and women) experience irritability, anger, sensitivity, anxiety and mood swings, the hallmark emotional symptoms of PMS. (Schmahmann, 2019).

These findings are leading scientists to conclude…

  1. During PMS, the cerebellum requires more energy to function properly than it does the rest of the month.
  2. If it doesn’t get enough energy, the cerebellum is thrown into dysfunction, causing the emotional symptoms of PMS.
  3. In an attempt to remedy the problem, the brain may crave quick, glucose-spiking foods to bring extra energy to the cerebellum.

Unfortunately, due to the way our bodies process sugar, a blood sugar spike inevitably leads to a blood sugar crash.

This leaves the cerebellum with less glucose than before, and symptoms return worse than prior to eating the junk food.


Only a few lifestyle modifications have been shown to reliably decrease the severity of emotional PMS symptoms.

They all work through pathways that support a stable supply of blood sugar to the brain, with less severe highs and lows. (Tsai, 2016).

They include:

  • Regular practice of yoga
  • Regular aerobic exercise
  • Regular High-Intensity Interval Training (HIIT)
  • Diets with lower glycemic loads (less sugar and simple carbohydrates)
  • Improved sleep hygiene (Regular, restful sleep for 8+ hours)
However, for many women, these changes only offer mild relief. And even women with picturesque healthy lifestyles still suffer from Emotional PMS.

Fortunately, there is another alternative solution that can both…

1. Support the healthy liver function needed to keep blood-sugar levels stable throughout the PMS period, giving the cerebellum the uninterrupted fuel source it needs

2. Support healthy mitochondrial function in the cerebellum, helping the brain use that steady supply of glucose as quickly and efficiently as possible during PMS


To understand how the supplemental ketone known as “thermally stabilized oxaloacetate” interacts with the root causes of PMS, you need to first understand its history.

Oxaloacetate (ox-a-lo-a-ce-tate), also known as OAA, has been known to science since it was discovered by Nobel Laureate Dr. Hans Krebs in the 1930s.

You may remember it from your high school biology class on mitochondria.

As part of the Krebs Cycle, OAA is a crucial component in how our cells turn glucose into energy.

However, because of the chemical makeup of OAA, it oxidizes (i.e. spoils), unless stored at sub-zero temperatures.

While scientists have been able to do some incredible things with supplemental OAA on a small scale, the necessity of storing the compound in specialized freezers has made it impractical to research on a large scale.

That is, until a physicist, Alan Cash, developed a chemical method to keep OAA shelf stable in a capsule just like any other vitamin.

As soon as the technology became available, scientists began researching the compound and it hit the shelves worldwide as an over-the-counter nutritional supplement.

Because of OAA’s relationship to the Krebs Cycle, it quickly became a common tool doctors recommended to patients to support healthy blood sugar levels and fight fatigue.

We used the technology to start a small, family-run biotechnology business, Terra Biological, and sold OAA supplements mostly to doctors and health care centers.

Then, something started happening that changed everything.

phone call

It started with a normal call from one of our regular customers, Dr. Humiston, a family practice physician. 

He called to place an order for his patients, and while I took down his information, he mentioned an interesting story. 

He said that a few months ago, he had recommended a daily OAA regimen to one of his patients struggling with fatigue.

Months later, she came back in for a check up, and told the doctor that while her fatigue was improving, she was much more excited about a different benefit of OAA. 

Ever since starting OAA supplementation, the PMS anxiety and mood swings she had struggled with since her teens had completely disappeared.

John Humiston, M.D. Family Price Physician Review


As weeks went by, we received more and more word from doctors about this curious benefit of OAA.

Along with many other physicians, Dr. Humiston started recommending OAA to other patients struggling with PMS.

A couple months later, we received this email from Dr. Humiston,

“I am up to almost 30 women treated for moody PMS….I have only had one failure.
Every other woman who has given me feedback has said that it substantially resolves emotional PMS symptoms, in a short time from taking the supplement…”


After receiving that email, the first thing I did was mail a bottle of OAA supplements to my daughter, who was in college at the time.

Since she had left home, we had received a series of phone calls from her at the same time each month.

We could hear her distraught, sad, angry and suffering, asking us for help, but no words or anything we did would make her feel better.

The worst feeling as a parent is hearing your child in pain but not being able to help.

Lo and behold, the next time our daughter called, she had stories to share, grades to brag about and sounded like herself again.

We waited a month, and then another, and fortunately the anxious, desperate voice never came back.


Our scientific research team prioritized investigation into why OAA, something that didn’t appear to impact female hormones at all, seemed so effective at relieving PMS.

Based on the old theories of PMS, it frankly didn’t make sense.

Weeks later, the team came back with a strong theory.

Increased Liver Function

The liver plays a key role in gluconeogenesis, a vital process that provides the right amount of glucose to the brain. Oxaloacetate is required for gluconeogenesis to work.

Normally, the body can produce enough OAA to survive without any problems, and it is found in trace amounts in many common foods. Any food with a high density of mitochondria (peas and pigeon breast have some of the highest amounts) will contain a small but measurable amount of OAA.

But during PMS, the cerebellum requires much larger amounts of sugar, and without enough oxaloacetate, the liver can’t keep up with the larger demand.

Supplementing with OAA allows more fatty acids to be converted into glucose, stabilizing glucose need with higher demands during PMS.

Healthy Brain Function

GABA, a neurotransmitter in the brain responsible for relieving anxiety and elevating mood, is always in a balancing act with glutamine, a neurotransmitter that, when in excess, causes toxic over-excitement of brain cells.


Scientific studies have shown that OAA supplements support the brain’s ability to bring itself into balance, lowering levels of glutamate when there is too much and raising levels of GABA when there isn’t enough. (Wilkins, 2014).


We knew this discovery had the potential of transforming the lives of millions of women. My daughter knew it, too.

And we knew that the women who would benefit from PMS relief deserved a woman-powered team to champion this cause.

So my daughter and I struck out on our own and founded Jubilance, a company to make PMS mood swings a thing of the past.

Our first order of business was developing clinical trials with the highest level of scientific rigor possible.

We put out requests into the medical research community, and within days, we were overwhelmed with support from medical professionals who knew this field of research was in dire need of attention.

So we ran our first clinical trial on oxaloacetate for PMS. The trial was designed to ensure the results ruled out any placebo-effect and any possible bias from scientists or study participants. The study was…

Double-blinded, placebo-controlled, crossover design, peer-reviwed, involved more than 60 participants

We were confident that the results would show significant relief from PMS, but when the numbers were finally crunched, the scientific team was floored by the results.

Daily OAA supplementation for just one month produced more emotional PMS relief on average than any other non-prescription intervention ever tested in clinical trials.

Clinical Trial of Oxaloacetate for Emotional Premenstrual Syndrome

  • Improvement in PMS-related Anxiety by 51%
  • Improvement in PMS-related Gloominess by 54%
  • Improvement in PMS-related Stress by 36%
  • Improvement in PMS-related Irritability by 18%
The clinial trial results made history.

Based on the clinical trial data, the FDA concurred with the first and only “structure/function” claim for an over-the-counter solution for Emotional PMS in U.S. history:

“Oxaloacetate may help alleviate the mild to moderate psychological and/or behavioral symptoms associated with Premenstrual Syndrome (PMS).”

With the validation of hard science, we launched Jubilance, an OAA supplement specifically for Emotional PMS relief.

Every capsule of Jubilance contains the same formula shown to relieve emotional PMS symptoms in clinical research.

Jubilance Supplement Facts. Vitamin C (Ascorbic Acide) 150mg. Oxaloacetate Thermally Stabilized Oxaloacetic Acid) 100mg. Other Ingredients: Vegetable Capsule.
3 Bottles of Jubilance Emotional PMS Support
PMS... Outsmarted.

Every week, we find more incredible reviews on Facebook. Here are some of our favorite screenshots:

Sheri: I've taken this for 2 months now, and it seriously works!!!!!
Mandy: I'm a believer! I was still emotional and still broke out, but I didn't want to stab someone like usual. I didn't get any hormonal migraines either. I did still have regular cramps on the first day, buut nothing Aleve didn't fix. My period has also been MUCH lighter. Not sure if that part is coincidence or the product, but I'll take it. Thank you from the bottom of my heart! My PMS was causing serious issues with my family because I was so mean and irritable, but not this time!
Amber: My boyfriend just said he has no idea when my period are anymore because he can't get a good read from my bad mood anymore.
Melissa: I purchased this product and began taking it immediately; I noticed a major difference! I have had major mood swings; which were really causing issues in my daily life; about 3-4 days a month, before my time of the month would begin. After taking this for a month; It eliminated all mood swings post PMS. I feel exactly the same as a normal day and I just purchase my second bottle. I also noticied I wasn't compulsive with eating like I would normally be during that time.
Heidi: This stuff has made me a normal person again, and each cycle get better. Highly recommend.
Shelby: Your product has worked wonders for my daughter, thank you so much! We were getting ready for pretty serious medication and I'm so glad we tried this frist! Thank you!!!!!
Erin: Sabrina this stuff is seriously amazing. Sabrina: Erin - thanks! I need to order some!

But there’s a catch: Jubilance doesn’t work for everyone.

Every body is unique, and no single solution will work the same for everyone.

Of the more than 3,000 women who have tried Jubilance so far, 76% purchase a second bottle or more.

That means a significant portion of women don’t respond with enough PMS relief to justify taking a daily supplement.

The only way to know if OAA will give you the PMS relief you deserve is to try it yourself.

So we created a deal for first-time customers to run your own personal PMS experiment, risk-free.

See for yourself if Jubilance is right for you with our 100% money-back guarantee and first-time customer discount.

A single bottle of Jubilance is $49 on Amazon.

A monthly subscription costs only $42 a bottle with free shipping.

But through this page only, first-time customers can try the first bottle of a Jubilance subscription for just $19.95.

It comes with your first month of a Jubilance subscription plus everything you need to find out if Jubilance works for you.

100% Money-back Guarantee

No need to mail back the bottle.

No hoops to jump through.

No red tape.

No explanation needed.

If your first bottle of Jubilance doesn’t work for you, shoot us an email or facebook message and we’ll issue a full refund right away.

Free and Discreet Shipping

Fast, free shipping to anywhere in the United States.

Cancel Anytime

Cancel your monthly subscription at any time with just a few clicks via, easy as pie.

Fighting Emotional PMS and Winning with Jubilance ebook

Free ebook copy of “Fighting Emotional PMS and Winning with Jubilance”

A $16.95 value for free. Learn about the science of PMS and how to stop it, packaged in a thorough but easily digestible primer.

Free Mood Relief Quiz

Track your improvement with lifetime access to our comprehensive symptom tracker quiz.

Free Access to a Private, Support Community

Gain access to our private Facebook Group “Bye PMS” to trade experiences and learn from a thriving community of women taking charge of their emotional health.

Ready to outsmart your PMS?


More screenshots from Facebook chatter about Jubilance:

Amber: Dudes! I tried it because my PMS symptoms have gotten out of control over the last few years. Best impulse buy in the history of time!!! The first month I only felt a little less like a monster, but I thought 'hey, I'll take it...' but the next month my irritability had almost disappeared, and now after I think 3 months, the only thing letting me know I'm PMSing is how tired I get for a few days. Everything else that was making me feel like an emotional nut bag is almost nonexistent. I had it all depression, anxiety, irritability. mood swings, insatiable hunger.. all drawing out for a week. I can't express how worth it this is for me. It made me feel like I took control of myself back. I strongly recommend trying it.
Emily: This works! Finally, something that really works.
Casey: Just started my second period while taking Jubilance and the 2nd month is even better then the first!! SIGNIFICANTLY less mood swings, no sugar cravings, no water weight gain, OR cramps this month!!! Yippee!! I'm also on BHRT (over a year now), so this is the icing on the cake for me! (I've tired everything) I know I'll never be without it! THE ABSOLUTE BEST CUSTOMER SERVICE, TOO!!!

Madison joined us over video chat to talk about her life-changing experience with Jubilance. Check out the highlights below.